A Comprehensive Analysis of Association between Several Candidate Genes and Rheumatoid Arthritis in Samples from North American Rheumatoid Arthritis Consortium (NARAC)∗
نویسندگان
چکیده
Several candidate-genes for Rheumatoid Arthritis are studied using multi-marker association scores based on 839 cases and 855 unrelated controls from the North American Rheumatoid Arthritis Consortium (NARAC) as part of the Genetic Analysis Workshop 15 data. Strong signals previously identified on PTPN22 and PADI4 were repeated in our findings. We also found significant association evidence that leads to an association network among the loci of PTPN22, PADI4, DLG5, SLC22A4, SUMO4 and CARD15. To account for false positives, we used permutations to have the family type I error rate controlled under 1%.
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